" Zollinger-Ellison syndrome in dogs "

Zollinger-Ellison syndrome is a rare disorder caused by a tumor called a gastrinoma. The tumor secretes the hormone gastrin, which causes excess production of gastric acid, leading to severe recurrent ulcers of the esophagus, stomach, duodenum, and jejunum. The syndrome is characterized by severe peptic ulcer disease caused by gastrin-secreting neuroendocrine tumors, most commonly located in the duodenum and pancreas. Frequently gastrinomas are not recognized at initial clinical presentation and are often mistreated. Symptoms that should raise suspicion of a gastrinoma include idiopathic peptic ulcer disease or long-standing refractory diarrhea. The term gastrinoma is interchangeably used with ZES